Complicated Dementia
How deplorable the spectacle presented by this young monomaniac, who, strong robust, full of life, and destined to a brilliant future, at the age of thirty years, in consequence of some trifling discussions respecting matters which were to him of some interest, persuades himself that he is the possessor of an immense fortune, which he inconsiderately spends, and believes to be an object of desire with all. He purcheses unnecessarily, and withut reason, every thing that offers; furniture, horses, carriages, pictures, etc. etc., and yields himself at the same time to all the excesses of the most fashionable life. The counsels of his relatives and friends fail to bring him back to the path of moderation in his thoughts, desires, or conduct; which a little before they admired. becoming excessively susceptible,he is irritated, and thrown into a transport of passion by the slighest observation. He refuses all medicine; assuring those around him that he was never so well or so happy. He was brought to Paris by Doct. K., physician equally skillful and estimable. 'I commit to your care,' says my confrère, 'a very interesting patient who is but slightly excited, and whom I have widhdrawn from scenes calculated to augment this excitement, which you will speedily cure.'
 
 

What did Esquirol find in his interview of this patient?

What was the outcome in this case?

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

I converse with the patient who speaks to me of his fortune, his projects of happiness for himself and his friends, of the numerous acquisitions which he is to make in Paris, etc. etc. After half an hour's conversation, 'What do you think?' says my learned froend. ' I think that your patient is incurable; that he will not recover, nor survive a year. Remain in Paris, and you will see, as the malady is making rapid progress.'
    In conversation with the patient, I had remarked some hesitation in the pronunciation of certain words, and undue readiness with which he had consented to remain in a private hospital. More extensive observation enabled ma to obtain a glimpse of certain slight defects of memory, and a forgetfulness of the projects of the evening previous. I was struck by the indifference and the air of contentment which tha patient manifested, though deprived of his liberty, and incapable of gratifying his caprices. He deferred daily to the morrow, the accomplishemnt of projects, which at first he wished to execute instantly.
 

What was Esquirol's diagnosis?
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

Complicated dementia...exists in connection with lypemania, mania, epilepsy, convulsions, sucrvy, and especially paralysis. Complicated dementia is incurable. Hippocrates has set down as a mortal sympotm in acute maladies, the complication of delirium with any variety of convulsions. What the father of medicine has said respecting acute diseases, is applicable to insanity, and particularly to dementia. The complication of mental diseases with lesions of motion, resists every curative measure and leaves no hope of protracted existence. ...In 1805, I first called attention to this phenomenon, and established by proof, the incurability of insanity complicated by paralysis.  This form of paralysis is often the sign of chronic inflammation of the meninges, and should not be confounded with paralysis which is consecutive to cerebral hemorrhages, cancers, tubercles, and softenings of the brain.
        It appears, now with the first symptoms of delirium, during the period of acuity, so remarkable at the commencement of almost all forms of insanity; now, it precedes the delirium; and now, joins
itself in some sort to it. Finally, whatever may be the epoch at which paralysis appears, its invasion sometimes
takes place without grave phenomena; and sometimes, it is the result of congestions, cerebral fevers,
epileptiform convulsions etc. At first, it is partial; it then invades a greater number of muscles and becomes
general. Its progress is regular; it goes on constantly increasing, while the understanding grows weak. Whatever
may be the character of the delerium, it indicates a speedy transition from insanity to chronic dementia; It is
rare that insane paralytics live more than from one to three years; and among them, the strongest and most
robust die most suddenly. Generally, the last moments of life with these patients are marked by convulsions,
cerebral congestions, visceral phlegmasia, and gangrene, which embraces all that portion of the body which is
deprived of the power of motion, and upon which its weight reposes.

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At the expiration of fifteen days the embarrassment of the tongue had increased; loss of memory is more frequently made manifest and before the close of the month, his step is less easy, and he grows lean, although eating largely. Leeches are repeatedly employed; a seton is inserted in the neck and valerian is prescribed as well as laxatives, to prevent constipation.
        Nothing succeeded in staying the progress of the inflamation of the meninges, and consequently that of the paralysis. At the expiration of three months his ideas were almost extinct; he no longer remembered any thing; and merely uttered words without any connection; repeating often, million, horses, château, carriage, etc. etc. He conducts like a child; totters in his gait; and sometimes discharges his urine involuntarily. By slow degrees, he becomes more feeble; no longer speaks but in a low voice; and never leaves his armchair, unless he is induced to walk, and sustained beneath both arms. His appetite is at all times voracious.
        At the fifth month, the patient scarcely articulates, and can no longer be understood.  The dejections are involuntary, although the matters are solid, and the urine is discharged unconsciously, both day and night. Finally, at the commencement of the sixth month, he is confined himself to bed; suffered for two days from epileptiform confulsions, and at the expiration of seven months sunk from a disease, which, which at its commencement, appeared so trifling that the experience of a distinguished physician failed to recognize it [Esquirol, 1845/1965, 435-7].
 

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