Stephen H. Gregory, Ph.D.

Associate Professor of Medicine

Address:

Department of Medicine
Rhode Island Hospital
Brown Medical School
432 Pierre M. Galletti Building
55 Claverick St.
Providence, Rhode Island 02903
Telephone: 401-444-7369
FAX: 401-444-7524
Email: sgregory@lifespan.org

Research Interests:

Current research efforts focus, in part, on delineating the role of the liver in host resistance to systemic bacterial infections using listeriosis in mice as an experimental model. The majority of pathogens that enter the bloodstream are taken up and eliminated within the liver. The specific mechanisms that underlie the extraordinary capacity of the liver to clear and kill these pathogens remain to be determined. Listeria monocytogenes is a gram-positive coccobacillus capable of replicating intracellularly and causing severe, sometimes fatal infections in humans. Listeriosis in mice is a prototypic model used extensively to study the factors that effect immunity to a wide variety of intracellular pathogens. The bulk of L. monocytogenes injected intravenously into non-immune animals and taken up in the liver where hepatocytes constitute the principal site of intracellular listerial replication. Listeriae injected intravenously into immune mice, are taken up by hepatocytes and rapidly eliminated. A variety of cell types and soluble factors have been implicated in recovery from primary listerial infections and protective immunity to subsequent infections. Ongoing experiments are designed to determine the mechanisms that underlie the effects of such factors on the replication of L. monocytogenes within hepatocytes in vitro and in vivo.

Selected Publications:

Harty MW, Huddleston HM, Papa EF, Puthawala T, Tracy AP, Ramm GA, Gehring S, Gregory SH, Tracy TF Jr Repair after cholestatic liver injury correlates with neutrophil infiltration and matrix metalloproteinase 8 activity. Surgery. 2005 Aug;138(2):313-20.

Wesche-Soldato DE, Chung CS, Lomas-Neira J, Doughty LA, Gregory SH, Ayala A. In vivo delivery of caspase-8 or Fas siRNA improves the survival of septic mice. Blood. 2005 Oct 1;106(7):2295-301.

Gehring S, Gregory SH, Kuzushita N, Wands JR.Type 1 interferon augments DNA-based vaccination against hepatitis C virus core protein. J Med Virol. 2005 Feb;75(2):249-57.

Wu H, Prince JE, Brayton CF, Shah C, Zeve D, Gregory SH, Smith CW, Ballantyne CM. Host resistance of CD18 knockout mice against systemic infection with Listeria monocytogenes. Infect Immun. 2003 Oct;71(10):5986-93.

Lomas JL, Chung CS, Grutkoski PS, LeBlanc BW, Lavigne L, Reichner J, Gregory SH, Doughty LA, Cioffi WG, Ayala A.  Differential effects of macrophage inflammatory chemokine-2 and keratinocyte-derived chemokine on hemorrhage-induced neutrophil priming for lung inflammation: assessment by adoptive cells transfer in mice. Shock. 2003 Apr;19(4):358-65.

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