Steven Moss, M.D.

Associate Professor of Medicine

Address:

Liver Research Center
55 Claverick Street, 4th Floor
Providence, RI 02903
phone: 401-444-6713
fax: 401-444-2939
E-mail:smoss1@pol.net

Clinical Interests:

I am interested in diseases of the stomach, small bowel, and colon including gastric and colon cancer.

Research Interests:

My research interests are in the pathogenesis of cancers of the gastrointestinal tract in general, and gastric cancer in particular. The causes of most gastrointestinal tract cancers remain obscure, but recently there has been considerable interest in the role of a bacterium, Helicobacter pylori, in gastric cancer. This organism is found commonly in the human stomach and is highly adapted for infection lasting decades. Its presence is associated with peptic ulcer disease, chronic gastritis and gastric adenocarcinoma, but how this bacterium causes disease is not well understood. We have been examining interactions between H. pylori and the human gastric epithelium which may be relevant to the pathogenesis of these diseases.

Helicobacter pylori bacteria attach to gastric epithelial cells and induce specific changes in cellular function. Our research is focused specifically on mechanisms by H. pylori alters apoptosis and cell cycle progression in gastric carcinogenesis.

Kim SS, Meitner P, Konkin TA, Cho YS, Resnick MB, Moss SF.Altered expression of Skp2, c-Myc and p27 proteins but not mRNA after H. pylori eradication in chronic gastritis. Mod Pathol. 2006 Jan;19(1):49-58.

Kuzushita N, Rogers AB, Monti NA, Whary MT, Park MJ, Aswad BI, Shirin H, Koff A, Eguchi H, Moss SF. p27kip1 deficiency confers susceptibility to gastric carcinogenesis in Helicobacter pylori-infected mice. Gastroenterology. 2005 Nov;129(5):1544-56.

Resnick MB, Gavilanez M, Newton E, Konkin T, Bhattacharya B, Britt DE, Sabo E, Moss SF.Claudin expression in gastric adenocarcinomas: a tissue microarray study with prognostic correlation. Hum Pathol. 2005 Aug;36(8):886-92.

Moss SF, Blaser MJ. Mechanisms of disease: Inflammation and the origins of cancer.
Nat Clin Pract Oncol. 2005 Feb;2(2):90-7.

Eguchi H, Carpentier S, Kim SS, Moss SF.P27kip1 regulates the apoptotic response of gastric epithelial cells to Helicobacter pylori. Gut. 2004 Jun;53(6):797-804.

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