Shuping Tong, M.D., Ph.D.

Associate Professor of Medicine

Address:

Liver Research Center
55 Claverick Street, 4th Floor
Providence, RI 02903
phone: 401-444-7365
fax: 401-444-2939
E-mail:Shuping_Tong_MD@Brown.edu

Research Interests:

My research interests involve investigations of hepadnaviral receptor proteins on hepatocytes. Using related duck hepatitis B virus (DHBV) as a model, we have identified p170, or duck carboxypeptidase D (DCPD), as a binding partner for viral pre-S envelope protein. Studies are in progress to define the contact site on the p170 for the pre-S1 region of DHBV. Another major interest is the study of HBV varients with altered replication capacity at the molecular level. We study HBV genomes amplified with patients with low and high level viremia with acute and chronic hepatitis and assess their replication capacity in transfected hepatocellular carcinoma cell lines.

Selected Publications:

Guarnieri M, Kim KH, Bang G, Li J, Zhou Y, Tang X, Wands J, Tong S. Point mutations upstream of hepatitis B virus core gene affect DNA replication at the step of core protein expression. J Virol. 2006 Jan;80(2):587-95.

Bang G, Kim KH, Guarnieri M, Zoulim F, Kawai S, Li J, Wands J, Tong S.Effect of mutating the two cysteines required for HBe antigenicity on hepatitis B virus DNA replication and virion secretion. Virology. 2005 Feb 5;332(1):216-24.

Khan N, Guarnieri M, Ahn SH, Li J, Zhou Y, Bang G, Kim KH, Wands JR, Tong S.Modulation of hepatitis B virus secretion by naturally occurring mutations in the S gene. J Virol. 2004 Apr;78(7):3262-70.

Li J, Tong S, Lee HB, Perdigoto AL, Spangenberg HC, Wands JR.Glycine decarboxylase mediates a postbinding step in duck hepatitis B virus infection. J Virol. 2004 Feb;78(4):1873-81.

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