Jack R. Wands, M.D.

Jeffrey and Kimberly Greenberg - Artemis and Martha Joukowsky Professor in Gastroenterology and Professor of Medical Science
Director, Liver Research Center and Division of Gastroenterology

Address:

Liver Research Center
55 Claverick Street, 4th Floor
Providence, RI 02903
phone: 401-444-7441
fax: 401-444-2939
E-mail:Jack_Wands_MD@Brown.edu

Research Interests:

Our research efforts involve the role of hepatitis B and C infection in the pathogenesis of hepatocellular carcinoma at the molecular level. We are particularly interested in signal transduction pathways that are associated with transformation of hepatocytes to the malignant phenotype. There are ongoing studies to develop antiviral strategies for chronic hepatitis B infection that include antisense oligonucleotides, ribozymes, dominant negative mutants and therapeutic DNA based vaccines. Since chronic HBV and HCV infection is associated with the development of hepatocellular carcinoma, we have a targeted gene therapy program for treatment of this devastating disease.

Clinical Interests:

My clinical interests are in hepatology with particular emphasis on the pathophysiology of viral hepatitis and human hepatocellular carcinoma.

Lee HC, Kim M, Wands JR. Wnt/Frizzled signaling in hepatocellular carcinoma. Front Biosci. 2006 May 1;11:1901-15.

Guarnieri M, Kim KH, Bang G, Li J, Zhou Y, Tang X, Wands J, Tong S. Point mutations upstream of hepatitis B virus core gene affect DNA replication at the step of core protein expression. J Virol. 2006 Jan;80(2):587-95.

Gehring S, Gregory SH, Kuzushita N, Wands JR. Type 1 interferon augments DNA-based vaccination against hepatitis C virus core protein. J Med Virol. 2005 Feb;75(2):249-57.

Merle P, Kim M, Herrmann M, Gupte A, Lefrancois L, Califano S, Trepo C, Tanaka S, Vitvitski L, de la Monte S, Wands JR.Oncogenic role of the frizzled-7/beta-catenin pathway in hepatocellular carcinoma. J Hepatol. 2005 Nov;43(5):854-62.

Merle P, de la Monte S, Kim M, Herrmann M, Tanaka S, Von Dem Bussche A, Kew MC, Trepo C, Wands JR. Functional consequences of frizzled-7 receptor overexpression in human hepatocellular carcinoma. Gastroenterology. 2004 Oct;127(4):1110-22.

Wands JR. Prevention of hepatocellular carcinoma. N Engl J Med. 2004 Oct 7;351(15):1567-70.

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