| RESEARCH
SUMMARY
My laboratory is mainly interested in the molecular and biochemical basis of parasitic diseases. We are currently investigating several basic molecular pathways in African trypanosomes. These include RNA processing and trafficking, antigenic variation, mitochondrial biogenesis and developmental control of gene expression. In addition, we are studying the mechanism of innate resistance of humans to trypanosomes and the mechanisms used by the parasites to circumvent human resistance. Recently, we have begun to explore the role of innate factors in modulation of the severity of malaria in humans and the relationship of this phenomenon to innate resistance to trypanosomes. Finally, we have initiated collaborative studies to determine the structure of the small nucleolar RNA U3 complex with pre-ribosomal RNAs in trypanosomes and malaria. We are investigating the potential for targeting this complex for drug development.
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PUBLICATIONS
McManus, M.T., Adler, B.K., Pollard, V.W. and Hajduk, S.L. (2000) Trypanosoma brucei gRNA poly(U) tail formation is stabilized by cognate mRNA. Molec. Cell. Biol. 20, 883-891.
Bertrand, K.I. and Hajduk, S.L. (2000) Import of a constitutively expressed protein into mitochondria from procyclic and bloodstream forms of Trypanosoma brucei. Molec. Biochem. Parasitol.106, 249-260.
Grams, J., McManus, M. and Hajduk, S.L. (2000) Processing of polycistronic guide RNAs is associated with RNA editing complexes in Trypanosoma brucei. EMBO J. 19, 5525-5532.
McManus, M., Shimura, M., Grams, J. and Hajduk, S.L. (2001) Identification of candidate mitochondrial RNA editing ligases from Trypanosoma brucei. RNA 7, 167-175.
Madison-Antenucci, S. and Hajduk, S.L. (2001) RNA editing associated protein-1 binds pre-edited mRNA. Molec. Cell 7, 879-886.
Shimamura, M., Hager, K.M., and Hajduk, S.L. (2001) The lysosomal targeting and intracellular metabolism of trypanosome lytic factor by Trypanosoma brucei brucei. Molec. Biochem. Parasitol. 115, 227-237.
Drain, J., Bishop, J. and Hajduk, S.L. (2001) Haptoglobin related protein mediates trypanosome lytic factor binding to trypanosomes. J. Biol. Chem. 276, 30254-30260.
Barker, C., Barbour, K.W., Berger, F.G. and Hajduk, S.L. (2001) Activity of human trypanosome lytic factor-1 in mice. Molec. Biochem. Parasitol. 117, 129-136.
Bishop, J. R., Shimamura, M., and Hajduk, S.L. (2001) Insight into the mechanism of human serum killing of African trypanosomes. Molec. Biochem. Parasitol. 118, 33-40.
Hatada, S., Seed, J.R., C. Barker, Hajduk, S.L., Black, S.J. and Maeda, N. (2002) No trypanosome lytic activity in the sera of mice producing human haptoglobin-related protein. Molec. Biochem. Parasitol. 119, 291-294.
Madison-Antenucci, S., Grams, J., and S.L. Hajduk (2002) Editing Machines: The Complexities of Trypanosome RNA Editing. Cell 108, 435-438.
Grams, J., Morris, J.C., Drew, M.E., Wang, Z., Englund, P.T., and S.L. Hajduk (2002) Transcription and Priming Replication of Kinetoplast DNA Maxicircles by a Mitochondrial RNA Polymerase. J. Biol. Chem. 277, 16952-16959.
Priest, J.W. and Hajduk, S.L. (2003) Trypanosoma brucei cytochrome c1 is imported into mitochondria along an unusual pathway. J. Biol. Chem. 278, 15084-15094.
Sherrer, R.A., Yermovsky-Kammerer, A., and Hajduk, S.L. (2003) A sequence motif within trypanosome precursor tRNAs influences abundance and mitochondrial localization. Molec. Cell. Biol. 23, 9061-9072.
Imrie, H., Ferguson, D., Carter, M., Drain, J., Shiflett, A., Hajduk, S.L. and Day, K. (2004) Light and electron microscopical observations of the effects of high-density lipoprotein on growth of Plasmodium falciparumin vitro. Parasitology 128, 577-584.
Wood, Z.A., Sabatini, R.S., & Hajduk, S.L. (2004) RNA Ligase: Picking up the Pieces. Molecular Cell 13, 1-2.
Imrie, H., Fowkes, F.J.I., Simmons, R.K., Watkins, C., Migot-Nabias F., Luty, A., Deloro, P., Tavul, L., Reeder, J., Hajduk, S.L. and Day, K. (2004) levels of haptoglobin-related protein in populations in Gabon and Papua New Guinea. Am. J. Trop. Med. Hyg. (In press).
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LAB
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