| RESEARCH SUMMARY
Research
interests include molecular virology, bacterial
pathogenesis, innate and cancer immunity,
signal transduction, cell growth and apoptosis,
tumor suppresser, transcription and molecular
bases of human diseases.
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PUBLICATIONS
Stanimir Ivanov; Ana-Maria Dragoi; Dominic Van Essen; Jennifer Louten; George Yap;Yinsheng Wan; Christine A Biron; Marco E Bianchi; Haichao Wang; Wen-Ming Chu. HMGB1 is a cofactor for TLR9 in mediating cellular responses to immunostimulatory DNA (Submitted to Blood).
XY Wang, ZG Bi, WM Chu, YS Wan (2005). IL-1 receptor antagonist inhibits MMP-1 production of UVA-irradiated human skin fibroblasts cultured with medium from UVB-irradiated keratinocytes. Int J Mol Med. 16(6):1117-24.
JP Xia, XZ Song, ZG Bi, WM Chu, YS Wan (2005). EGCG attenuates UV-induced apoptosis, NFkB activation, and expression of proinflammatory cytokines and MMPs in cultured human keratinocytes in vitro. Int J Mol Med. 16(5):943-50.
Zhang P, Dragoi AM, Chen J, Gong X, Ivanov S, Chuang T, Li Z-W, Tuthill C, Wan Y, Karin M and Chu WM (2005). Activation of IKK and NF-kB by thymosin alpha 1 requires the TRAF6 and aPKC pathway. EMBO Report, 6(6): 531-7.
Dragoi AM; Fu X; Ivanov S; Zhang P; Shen L; Wu D; Li GC and Chu WM (2005). DNA-PKcs, but not TLR9 is required for activation of Akt by CpG-DNA. EMBO J. 24(4):779-89.
Chu WM; Gong X; Li ZW;
Takabyashi K; Yi Chen; Ouyang HH; Lois A;
Chen DJ; Li GC; Karin M and Raz E* (2000).
DNA-PKcs is required for the innate immunity
by immunostimulatory DNA. Cell, 103,
909. *Corresponding author.
Chu WM;
Ostertag D; Li ZW; Chang, LF; Chen Y; Hu
YL; Williams BRG; Perroult J and Karin M
(1999). JNK2 and IKK-beta are required for
activating the innate response to viral
infection, Immunity, 11:721. Li ZW;
Chu WM; Hu YL; Dalhase M; and Karin M (1999).
Role of IKK-beta in the activation of IkB
kinase and NF-kBand cell survive defined
by targeted gene disruption, J Exp. Med.
Jun, 7, 118-345.
LAB MEMBERS
Xin Wang, Ph.D., Senior Research Associate
Xiao Peng, Ph.D., Postdoctoral Research Associate
Ana-Maria Dragoi, Pathobiology Graduate Student
Matthew Riolo, Pathobiology Graduate Student
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