MPPB Faculty
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- Wayne Bowen
- Professor of Biology, Co-director of MPP Graduate Program
- We study sigma receptors, proteins found throughout the body. They bind several classes of psychoactive drugs. Activation of sigma-2 receptors causes programmed cell death (apoptosis). We are trying to understand the underlying more>> mechanisms for this. Because they are highly expressed in cancer cells, we are targeting sigma-2 receptors for development of new antineoplastic agents. Also, antipsychotic drugs such as haloperidol damage neurons via sigma-2 receptors. Blocking sigma-2 receptors might prevent the irreversible motor side effects caused by typical neuroleptic agents.
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- Leon Goldstein
- Professor
- Investigation is aimed at elucidating the mechanisms that cells employ in regulating their volume under normal conditions and during osmotic stress. We are examining this question in fish, since many representatives of this group normally more>> encounter wide variations in osmolarity of the external environment and can tolerate marked perturbations in the osmotic pressure of their extracellular fluid.
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- Chi-Ming Hai
- Professor
- Our research is concerned with how mechanical force and deformation modulate airway smooth muscle responsiveness and remodeling. We take an integrative approach to this research area by performing experiments from muscle mechanics to gene more>> expression.
• Regulation of Airway Smooth Muscle Contraction
• G-Protein Coupled Receptor-Mediated and Mechanosensitive Modulation of Cytoskeletal Recruitment of Actin- and Integrin-Binding Proteins in Differentiated Airway Smooth Muscle
• Cholinergic Receptor- and Cyclic Stretch-Mediated Contractile and Inflammatory Cytokine Gene Expression in Differentiated Airway Smooth Muscle
• Podosome Formation in Cultured Vascular Smooth Muscle Cells and Alveolar Macrophages
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- Edward Hawrot
- Professor
- We pursue biochemical and pharmacological studies aimed at understanding the fundamental structure-function relationship of nicotinic acetylcholine receptors (nAChRs). We also study the molecular basis for the highly specific recognition more>> of muscle-type nAChRs by certain snake venom-derived toxins classified as alpha-neurotoxins. More recently, we have used homologous recombination techniques to construct a knock-in mouse in which the alpha3 gene encoding one subtype of neuronal nAChRs has been minimally mutated to impart pharmacological sensitivity to the classic nicotinic antagonist, alpha-bungarotoxin. These mice should enable a systematic determination of the role of alpha3-containing nAChRs in behavior and nervous system function.
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- Diane Hoffman-Kim
- Associate Professor
- The goal of the Hoffman-Kim laboratory is to understand axon guidance in complex environments and inform biomaterial and tissue engineering strategies for promoting nerve regeneration. We apply engineering techniques to biological systems more>> in vitro to challenge growing neurons with multiple guidance cues, including diffusible factors, substrate-bound molecules, electrical cues, and topographical surface features.
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- Julie Kauer
- Professor
- My laboratory focuses on understanding molecular mechanisms involved in synaptic plasticity and modulation of neuronal excitability using modern electrophysiological techniques in brain slices. Our work is related to understanding more>> fundamental processes in memory and in drug addiction.
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- Michael Lysaght
- Professor (Research)
- Michael J. Lysaght is the Director of Brown University's Center for Biomedical Engineering. His area of specialization is the therapeutic application of synthetic membranes in hemodialysis, apheresis, and tissue engineering. He also more>> studies and has recently described in several influential publications the complex interplay of technology, economics, and public policy in shaping contemporary and emerging organ-replacement therapies.
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- John Marshall
- Professor
- In response to hormonal or synaptic stimulation, excitable cells (including smooth muscle, cardiac muscle, and neurons) undergo a diversity of changes in their electrical properties. My lab is studying the trafficking and localization of more>> glutamate receptors and calcium channels to synapses, and their modulation by protein kinases.
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- Edith Mathiowitz
- Professor
- Research in our laboratory focuses on the polymer science-medicine interface. Areas of interest include development and modeling of novel drug delivery systems, particularly for the release of insulin and growth factors; designing more>> small-diameter vascular grafts with better compliance; development of novel bioadhesive polymers for oral delivery systems; liquid crystals as smart sensors; the use of nanoparticles as novel therapeutic delivery systems (nanomedicine), tissue markings, DNA delivery.
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- Jeffrey Morgan
- Associate Professor of Medical Science and Engineering CoDirector Center for Biomedical Engineering
- Research in the lab is focused on understanding the molecular and cellular biology of the skin with an eye towards new therapeutic approaches to wound healing, the repair of the skin and the improvement in the performance of percutaneous more>> medical devices. We are also working on novel devices containing living cells to profile gene expression, monitor the toxicity of nanomaterials, and to study the dynamics of the cell adhesion process.
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- Wolfgang Peti
- Assistant Professor
- The focus of my research group is to understand the molecular basis of synaptic transmission and synaptic plasticity. We combine the information derived from biomolecular NMR spectroscopy, X-ray crystallography, and additional biophysical more>> techniques, such as ITC, DSC, Biacore, and CD spectroscopy to derive the functional analysis of events in signaling in neurons, especially at the post synaptic density. Furthermore, my research group is pursuing the structure elucidation of membrane proteins.
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- Anita L. Zimmerman
- Professor
- Our research is in molecular and cellular aspects of the nervous system, with an emphasis on ion channels and the early stages of vision in rods and cones. An ion channel is a membrane protein with an internal pore that opens in response more>> to chemical and electrical signals, allowing passage of specific ions such as sodium and calcium. Ion channels are critically involved in functions as diverse as nerve impulses in the brain, the beating of the heart, visual perception, muscle contraction, learning and memory, hormone secretion and embryonic development. They are also the targets of many drugs, such as those used to treat pain and heart disease. Genetic defects in ion channels can cause devastating diseases, such as cystic fibrosis.
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Biomed Division
MPPB Faculty
Providence, RI 02912