Dr. Deborah McK. Ciombor's research focuses on cell-based tissue engineering to create a transplantable biocomposite cartilage replacement that may be able to restore function lost to trauma or disease. A stem cell population has been more>> identified in joint lining tissues (synovium) that can be differentiated into cartilage cells by exposure to specific sequences of growth factors.
Our research examines the mechanisms mediating contraction of the smooth muscle in the esophagus and Lower Esophageal Sphincter (LES). Disorders of esophageal motor function and LES competence, for instance gastroesophageal reflux disease, more>> affect more than one in ten adults over 40 and one in four adults over 60 years of age. We investigate the inflammation-associated changes in the signaling mechanisms mediating esophageal contraction that occur with gastroesophageal reflux disease.
My research interests lie at the intersection of materials science, electrochemistry, and biology, with broad interests in the areas of biomaterials, bioelectronics, and biocatalysis. Research projects in my laboratory include the more>> synthesis of new biocomposites (biocatalysts/conducting polymers/nanofibers) for use in batteries, fuel cells, and biomedical applications (e.g., biosensors, tissue engineering); and the design and fabrication of devices that use these new materials.
Professor Richardson has biomedical engineering research interests with five main themes: adhesion, aggregation and disintegration of cells and cell groups, with applications in thrombosis and hemostasis; artificial organs, especially more>> those designed for transport purposes such as artificial lungs and hybrid artificial pancreases; applications of ultrasound in detection and diagnosis, including intravascular usage, and corresponding image analysis; interaction of flow and blood vessel walls, especially for problems associated with atherosclerosis; design of devices and instruments with biomedical applications (where his research has led to patents).
Professor of Pathology and Laboratory Medicine (Research)
Autologous adult human skeletal muscle cells have numerous potential cell transplantation applications, including regenerating heart and skeletal muscle, and for therapeutic protein delivery when genetically engineered to express a more>> recombinant protein. Our research examines the survival and functionality of human muscle cells transplanted in vivo for the development of improved methods for the treatment of numerous endocrine, neuromuscular, and cardiovascular disorders.