Michael Lysaght
Education
Ph.D., UNSW Sydney Australia, 1990
Research
Professor Lysaght's area of specialization is the therapeutic application of synthetic membranes and other barrier materials in hemodialysis, apheresis, and tissue engineering. He also studies the complex interplay of technology, economics, and public policy in shaping contemporary and emerging organ-replacement therapies and has recently described this in several influential publications.
While at Brown, Dr. Lysaght's laboratory research has focused on new therapies for End Stage Renal Disease, and tissue engineering approaches to the treatment of diabetes and of deteriorating cartilage. His current research projects focus on delivery of orthopedically relevant growth factors from microencapsulated, genetically engineered cells.
Teaching
Dr. Lysaght retired from teaching in 2008. During most prior academic years, Dr. Lysaght taught three courses with an aggregate annual enrollment of 150-200 students: Organ Replacement (BI1080), Introduction to Biotechnology (BI0170), and Biotechnology Management (BI0080).
He received the Hazeltine Citation in 2003 and the Le Duc award for teaching excellence in Life Science in 2002.
Publications
- Lysaght MJ, Jaklenec A, Deweerd E. Great expectations: private sector activity in tissue engineering, regenerative medicine, and stem cell therapeutics. Tissue Eng part A 14: 305-15, 2008
- Cronin-Fine D, Gotch F, Levin N, Kotanko P, Lysaght MJ. A Mathematical model comparing solute kinetics in low and high BMI hemodialysis patients. Int J Artif Organs. 1000-7, 2007
- Paek HJ, Campaner AB, Kim JL, Golden L, Aaron RK, Ciombor DN, Morgan JR, Lysaght MJ. Microencapsulated Cells Genetically Modified to Overexpress Human Transforming Growth Factor-β1: Viability and Functionality in Allogeneic and Xenogeneic Implant Models. Tissue Eng 12(7):1733-9, 2006
- Paek HJ, Moise LJ, Morgan JR, Lysaght MJ. Origin of insulin secreted from islet like cell clusters derived from murine embryonic stem cells. Cloning and Stem Cells 7: 226-231, 2005
- O'Loughlin JA, Bruder JM, Lysaght M. In-vivo and In-vitro degradation of urea and uric acid by encapsulated genetically modified microorganisms. Tissue Engineering 10: 1446-55, 2004
- Lysaght MJ, O'Loughlin JA. Demographic scope and economic magnitude of contemporary organ replacement therapies. ASAIO J 46: 515-21, 2000.
- Buscher E, Goddard M, Heyd B, Joseph JM, Favre J, De Tribolet N, Lysaght M, Aebischer P. Immunoisolated xenogeneic chromaffin cell therapy for chronic pain. Anesthesiology 85: 1005-12, 1996.
- Aebischer P, Buscher E, Joseph J, Favre J, Lysaght M, Rudnick S. Transplantation in humans of encapsulated xenogeneic cells without immunosupression. Transplantation 58: 1275-7, 1994.
- Lysaght MJ, Vonesh EF, Gotch F, Ibels L, Keen M, Lindholm B, Nolph KD, Pollock CA, Prowant B, Farrell PC: The influence of dialysis treatment modality on the decline of remaining renal function. ASAIO J 37: 598-604, 1991.
- Chick WL, Perna JJ, Lauris V, Low D, Galletti PM, Panol G, Whittemore AD, Like AA, Colton CK, Lysaght MJ. Artificial pancreas using living beta cells: effects on glucose homeostasis in diabetic rats. Science 197:780-782, 1977.
- Colton CK, Henderson LW, Ford CA, Lysaght MJ. Kinetics of hemodiafiltration, I - in-vitro transport characteristics of a hollow fiber blood ultrafilter. J Lab Clin Med 85 (3): 355-371, 1975
- Silverstein ME, Ford CA, Lysaght MJ, Henderson LW. The treatment of intractable fluid overload. New Eng J Med 291:747-751, 1974.
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