Edith Mathiowitz MPPB Faculty

Edith Mathiowitz

Read Edith Mathiowitz's full Faculty Profile.

Professor

Phone: +1 401 863 1358

Email: Edith_Mathiowitz@Brown.EDU

Education

Ph,D., Weizman Institute of Science, Israel, 1985

Research

Research in our laboratory focuses on the interface between polymer science and biology. Areas of interest include:

Tissue engineering and drug ad gene delivery;

Development, modeling, and morphological analysis of novel drug delivery systems, particularly for the release of macromolecules, such as insulin and growth factors;

Synthesis and characterization of biomaterials for drug delivery systems;

Studies of polymer-protein interactions with emphasis in the development of bioerodible polymers involving the use of mild fabrication techniques;

Developing of bioadhesive polymers for use as oral delivery systems;

Design and development of modulated sensors that respond to external stimuli (e.g., light heat).

All of these studies are directed to create easier and more sophisticated ways to administer therapeutic agents into the body exactly where and when they are needed. Most therapeutic peptides and proteins easily degrade when taken orally and are too unstable to withstand packing in slow-release mechanisms - they all require frequent parenteral injections. Understanding the basics of delivery systems is the key for better medications in the future.

Studies of polymer-cell interaction, with particular emphasis on bioadhesion; development of the basic relationship between polymer structures (molecular and morphological) and living tissue; surface modification for enhancement of cell adhesion, an area of particular importance in the development of oral delivery systems as well as small vascular grafts.

Development of theoretical and experimental procedures to process microcapsules based on biomaterials; processing of polymeric composites based on microencapsulation. A wide range of polymers and polymer blends are investigated, including interpenetrating networks, amorphous, semicrystalline, and liquid crystal polymers.

Teaching

1992-present Annual speaker in a short course entitled "Formulation Development of Therapeutic Proteins and Drug Delivery Systems For Peptides and Protein Drugs. Controlled Release Systems for Proteins." organized by the American Chemical Society. Chicago, Illinois.

1992-present Teaching Bio 211, "Biomaterials," graduate level course. Biomaterials course is an overview of materials considered biocompatible.

1991-present Teaching Bio 109, "Polymers for Artificial Organs" an undergraduate/graduate level course serving as an introduction to polymer science.

1990 Lecturer in course on microencapsulation. "Microencapsulation and Nanoencapsulation - Process and Pharmaceutical Applications", Sponsored by the Controlled Release Society, Boston, May 14-15, 1990.

1979-1981 Lecturer of chemistry at the "Reali" Gymnasium, Rishon Le Zion, Israel.

1974-1975 Physics and chemistry lecturer in an adult education program at Israel Institute of Biological Research, Nes Ziona, Israel.

Courses

Artificial Organs/Biomaterials/Tissue Engineering Seminar (BI0223)
Artificial Organs/Biomaterials/Tissue Engineering Seminar (BI0224)
Drug and Gene Delivery (BI0211)
Polymer Science for Biomaterials (BI0109)

Publications

Claudia Carvalho-Queiroz1, Rosemary Cook1, Ching C. Wang2, Rodrigo Correa-Oliveira1, Nicola A. Bailey4, Nejat K. Egilmez1, Edith Mathiowitz4 and Philip T. LoVerde1,*Schistosoma mansoni cytosolic superoxide dismutase, a vaccine candidate that targets adult worms: cross-reactivity with host superoxide dismutase and identification of parasite-specific B epitopes. Infection and Immunity (IAI). In press.
E, Mthiowitz and J. Jacob. " a Novel Mechanism for spontaneous encapsulation of active agents: Phase Inversion Nanoencapsulation. Chapter in ACS book. In press.
N.A. Rahman, E. Mathiowitz. Localization of bovine serum albumin in double-walled microspheres. Journal of controlled release. 94,163-175,2004
J. Godbee, P. Pattamunuch, E. Scott, and E. Mathiowitz. Degradation of Multi-phase Microspheres Fabricated via Solvent Removal. Journal of Microencapsulation. 21(3) 2004: 331-352.
J. Godbee, E. Scot, P. Pattamunuch, S. Chen AND E. Mathiowitz "The role of solvent/non-solvent ratio on microsphere formation using the solvent removal method"Microencapsulation, Vol. 21, p 151-160, 2004.
CG Thanos, K-P. Yip, and E. Mathiowitz Intestinal Uptake of Polymeric Microspheres In The Rabbit Studies With Confocal Microscopy. Journal of Bioactive and Compatible Polymers, Vol. 19, July 2004: 247-266.
M. S. Sabel, J.Skitzki, L. Stoolman, N.K. Egilmez, E. Mathiowitz, N. Baily, W.J. Chang and A.E. Chang "Intratumoral IL-12 and TNF-a Loaded Microspheres leads To regression of Breast cancer and Systemic Anti –Tumor Immunity". Annals of Surgical Oncology, 11(2), 147 –156 2003
Hess SD, Egilmez NK, Bailey N, Anderson TM, Mathiowitz E, Bernstein SH,Bankert RB."Human CD4+ T cells present within the microenvironment of human lung tumors are mobilized by the local and sustained release of IL-12 to kill tumors in situ by indirect effects of IFN-gamma." J. Immunol. Jan 1;170(1):400-412, 2003.
CA Santos, BD Freedman, S Ghosn, JS Jacob, M Scarpulla, DJ Enscore, E Mathiowitz, "Effect of Polyanhudride Microsphere Composition on Bioadhesion. Evaluation of anhydride oligomers" Biomaterials, 24,3571-3583,2003
CG Thanos, Z Liu, M Goddard, J Reineke, N Bailey, M Cross, R Burrill,, E Mathiowitz, "Enhancing the Oral Bioavailabliity of the Poorly Soluble Drug Dicumarol with a Bioadhesive Polymer" Accepted March 31, J Pharm Sci, 2002
CG Thanos, Z Liu, J Reineke, E Edwards, E Mathiowitz, "Improving the Bioavailability of the Poorly-Soluble Drug Dicumarol by using Micronization and the Formation of a Solid Solution" In press Pharm Res, 2002
DM Ciombor, Z Liu, C Thanos, N Rahman, P Weston, R Aaron, E Mathiowitz, "Investigation of Protein microencapsulation by PLGA using W/O/O Emulsion and Solvent Removal: The Effect of Fabrication Parameters on Size distribution, morphology, and release of bovine serum albumin"
CG Thanos, Z Liu, YS Yong, JS Jacob, M Sandor, E Edwards, E Mathiowitz. "Improving the Oral Bioavailability of Poorly Soluble Drugs: The Effects of Formulating Dicumarol with a Bioadhesive Polyanhydride in the Rat", Pharmaceutical research accepted March 31.