David J Morris, D. Phil.

Director of Biochemistry and Clinical Immunology, Lifespan AMC
Professor of Pathology
dmorris@lifespan.org
T: 401 793 4231
F: 401 274 5154

The Miriam Hospital
Department of Pathology
164 Summit Avenue
Providence, RI 02906

Medical Education/Graduate Education:

Ph.D. in Organic Chemistry, St Catherines College, Oxford University, England. 1963

Fellowship:

Brown University, Division of Biological and Medical Sciences. 1963-1966

Board Certification:

Clinical Biochemistry 1968

Research Interests:

Mechanism of Action of Mineralocorticoids and Glucocorticoids and role of 11beta –hydroxysteroid dehydrogenase in kidney, vascular tissue, testis and other steroid hormone regulated target tissues. Isolation and Identification of endogenous 11beta –hydroxysteroid dehydrogenase inhibitors in Human disease states including Hypertension.

Current Approved Research Grants:

Co-Investigator NIH Grant HD33000 / Population Council, Rockefeller University, NY. Corticosteroids, Stress and Leydig Cell Function.

Most Recent Significant Publications:

Wang, G.-M, Ge, R-S, Latif,S.A, Morris, D.J, and Hardy, M.P. 2002. Leydig cells express 11b-hydroxylase message and 11b-hydroxlated androgens inhibit 11b-HSD1 enzymatic activity. Endocrinology. 143, 621- 626.

Morris, D.J., Brem, A.S., Ge, R., Jellinck, P.H., Sakai, R.R. and Hardy, M.P. 2003. At the Cutting Edge. The functional roles of 11beta-HSD1: vascular tissue, testis and brain. Mol.Cell. Endocrinol. 203, 1-12.

Ge, RS, Dong, Q, Sottas, CH, Latif, SA, Morris, DJ, Hardy, MP 2005. Stimulation of testosterone production in Leydig cells by aldosterone is mineralocorticoid receptor mediated. Mol Cell Endocrinol 243, 35-42.

Latif, SA, Pardo, HA, Hardy, MP, Morris, DJ 2005. Endogenous selectie inhibitors of 11beta-OH-steroid dehydrogenase isoforms 1 and 2 of adrenal origin. Mol Cell Endocrinol 243, 43-50.