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Sean P. David, MD, SM, DPhil
Director of Family Medicine Research and
Assistant Professor of Family Medicine
Email:
Sean_David@brown.edu
 He is an Assistant Professor of Family Medicine at the Warren Alpert Medical School of Brown University in Providence , Rhode Island . He is a graduate of the University of Washington School College of Arts and Sciences (B.S. Zoology) and School of Medicine (M.D.), the Harvard School of Public Health (S.M. Health & Social Behavior), and the University of Oxford (D.Phil. Pharmacology). He was Chief Resident in Family Practice at the New Hampshire-Dartmouth Family Practice Residency Program. Current and former mentors included former Surgeon General C. Everett Koop the late Sir Richard Doll. He is currently Director of Research in Family Medicine at The Warren Alpert Medical School of Brown University and the Primary Care Genetics Laboratory and Translational Research Center , and the C. Everett Koop Health Policy Fellowship.
Dr. Sean David is a family physician with formal training in public health, pharmacology, and genetics. His research focuses on the translation of basic biomolecular nicotine dependence research into personalized smoking cessation therapies in primary care through pharmacogenomics. Dr. David has conducted research with functional magnetic imaging of the brain, positron emission tomography, genomics (genome-wide microarray research and DNA sequencing), and pharmacogenetic clinical trials of bupropion and nicotine replacement therapy his research is identifying neural substrates for nicotine dependence and biobehavioral mechanisms and neurotransmitter that influence ability to quit smoking (e.g., cue-elicited craving). These studies have informed how genotype-based pharmacotherapies can effectively target genetic variation in these identified reward pathways to tailor smoking cessation therapies and maximize efficacy for smoking cessation. Current and future research also explores the impact of genetic feedback on self-efficacy for smoking cessation in pharmacogenetic clinical consultations, cost-effectiveness analysis of pharmacogenetics, and diffusion studies geared toward provision of genomic personalized medicine to all populations.
Dr. David is the recipient of the American Academy of Family Practice Advanced Research Training Award , the Robert Wood Johnson Foundation Generalist Physician Faculty Scholars Award, and a National Institute on Drug Abuse (K08) Mentored Clinical Scientist Development Award.
At Brown, he founded the Primary Care Genetics and Translational Research Center , the C. Everett Koop Health Policy Fellowship, and co-founded Ya No Fumo, a community-based smoking cessation program for Latino/Hispanic patients in Rhode Island .
Education
- B.S., University of Washington
- M.D., University of Washington
- Residency, NH Dartmouth Family Practice Residency
Program
- S.M., Harvard School of Public Health
- Fellowship, Cancer Research UK General Practice
Research Group, Department of Primary Health Care, University
of Oxford
- D.Phil., Pharmacology, University of Oxford
Research Interests
Translating biomedical tobacco use research into practice and
policy:
- Genetic influences on nicotine dependence
- Smoking cessation clinical trials, genetic
epidemiology, pharmacogenetics/pharmacogenomics, research
synthesis and evidence dissemination.
- Functional Neuroimaging
- Promoting genetics in primary care and translational
genetics research with implications for primary care physician
practice.
Selected Research Projects
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