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Selected Publications (from 2002 - present)
(For full list download Dr. Ayala's CV in pdf format)
Song, G.Y., Chung, C.S., Chaudry, I.H., Ayala, A. 2001. MAPK p38 antagonism as a novel method for inhibiting lymphoid immune suppression in polymicrobial sepsis. Amer. J. Physiol. 281:C662-C669 (PMID: 11443065).
Ayala, A., Chung, C.S., Lomas, J.L., Song, G.Y., Doughty, L.A., Gregory, S.H., Cioffi,W.G., LeBlanc, B.W., Reichner, J., Simms, H.H., Grutkoski, P.S. 2002. Shock induced neutrophil mediated priming for acute lung injury in mice: divergent effects of TLR-4 and TLR-4/FasL deficiency. Amer. J. Pathology 161:2283-2294 (PMID: 12466142).
Chung, C.S., Song, G.Y., Lomas, J., Simms, H.H., Chaudry, I.H., Ayala, A. 2003. Inhibition of Fas/Fas ligand (FasL) signaling during sepsis has tissue specific effects on macrophage apoptotic and functional capacity. J. Leukocyte Biol. 74:344-351(PMID: 12949237).
Lomas, J.L.,Chung, C.S., Grutkoski, P.S., LeBlanc, B.W., Lavigne, L., Reichner, J., Gregory, S.H., Doughty, L.A., Cioffi, W.G., Ayala, A. 2003. Differential effects of MIP-2 and KC on hemorrhage induced neutrophil priming for lung inflammation: assessment by adoptive cell transfer in mice. Shock 19:358-365 (PMID: 12688548).
Rhee, R.J., Carlton, S., Lomas, J.L., Lane, C., Brossay, L., Ayala, A. 2003. Inhibition of CD1d activation suppresses septic mortality: a role for NK-T cells in septic immune dysfunction. J. Surg. Res. 115:74-81 (PMID: 14572776).
Grutkoski, P.S., Chen, Y., Chung, C.S. and Ayala, A. 2003. Sepsis-induced SOCS-3 expression is immunologically restricted to phagocytes. J. Leukoc. Biol. 74:916-922 (PMID: 12960286).
Grutkoski, P.S., Chen, Y., Chung, C.S., Cioffi, W.G. and Ayala, A. 2004. Putative mechanism of hemorrhage-induced leukocyte hyporesponsiveness: induction of suppressor of cytokine signaling (SOCS)-3. J. Trauma 56:742-748 (PMID: 15187736).
Lomas-Neira, J.L., Chung, C.S., Grutkoski, P.S., Miller, E.J., Ayala, A. 2004. CXCR2 inhibition suppresses hemorrhage induced priming for acute lung injury in mice. J. Leukoc. Biol. 76:58-64 (PMID: 15123771).
Ding, Y., Chung, C.S., Bray, S., Chen, Y., Grutkoski, P.S., Carlton, S., Albina, J.E., Ayala, A. 2004. Polymicrobial sepsis induces divergent effects on splenic and peritoneal dendritic cell function in mice. Shock 22:137-144 (PMID: 15257086).
Song, G.Y., Chung, C.S., Cioffi, W.G., Ayala, A. 2005. Insights into the contribution of STAT4 and STAT6 signaling to the morbidity seen in a low-mortality model of sepsis. Intensive Care Med. 31:1564-1569 (PMID: 16172848).
Lomas-Neira, J.L., Chung, C.S., Wesche, D.E., Perl, M., Ayala, A. 2005. In vivo gene silencing (with siRNA) of pulmonary expression of MIP-2 vs. KC results in divergent effects on hemorrhage induced neutrophil mediated septic acute lung injury. J. Leukocyte Biol. 77:846-853 (PMID: 15695553).
Wesche-Soldato, D.E., Chung, C.S., Lomas-Neira, J., Doughty, L.A., Gregory S. H., Ayala, A. 2005. In vivo delivery of caspase 8 or FAS siRNA impoves the survival of septic mice. Blood. 106:2295-2301 (PMID: 15941915).
Perl, M., Chung, C.S., Lomas-Neira, J., Rachel, T.M., Biffl, W.L., Cioffi, W.G., Ayala, A. 2005. Silencing of Fas- but not caspase-8 in lung epithelial cells ameliorates experimental acute lung injury. Amer. J. Pathol. 167:1545-559 (PMID: 16314469).
Lomas-Neira, J.L., Perl, M., Chung, C.S., Ayala, A. 2005. Shock and hemorrhage: An overview of animal models. Shock 24 (Suplt. 1): 33-39 (REVIEW; PMID: 16374370).
Perl, M., Chung, C.S., Ayala, A. 2005. Apoptosis. Crit. Care Med.-Supplt. 33:S526-S529 (REVIEW; PMID: 16340441).
Wesche, D.E., Lomas-Neira, J.L., Perl, M., Chung, C.S., Ayala, A. 2005. Leukocyte apoptosis and its significance in sepsis and shock. J. Leukocyte Biol. 78:325-337 (REVIEW; PMID: 15817707).
Lomas-Neira, J., Chung, C.S., Perl, M., Gregory, S., Biffl, W., Ayala, A. 2006. Role of alveolar macrophage & migrating neutrophils in hemorrhage induced priming for ALI subsequent to septic challenge. Amer. J. Physiol. 290:51-58 (PMID: 16157517).
Chung, C.S., Watkins, L., Song, G.Y., Lomas, J., Cahoone, E.V., Cioffi, W.G., Ayala, A. 2006. Deficiency in gd T-lymphocytes compromises the ability of mice to survive polymicrobial sepsis. Amer. J. Physiol. 291:R1338-1343 (PMID:16878028).
Chung, C.S., Chen, Y.P., Grutkoski, P.S., Doughty, L.A., Ayala, A. 2007. SOCS-1 is a central mediator of steroid-increased thymocyte apoptosis and decreased survival following sepsis. Apoptosis 12:1143-1153 (PMID: 17380787).
Swan, R., Chung, C.S., Albina, J.E., Cioffi, W.G., Perl, M., Ayala, A. 2007. Polymicrobial sepsis enhances apoptotic immune cell clearance by splenic macrophages. Surgery 142:253-261 (PMID: 17689693).
Wesche-Soldato, D.E., Chung, C.S., Gregory S. H., Salazar-Mathers, T.P., Ayala, C.A., Ayala, A. 2007. CD8+ T cells promote inflammation and apoptosis in the liver after sepsis: role of Fas-FasL. Amer. J. Pathol. 171:87-96 (PMID: 17478568).
Perl, M., Chung, C.S., Perl, U., Lomas-Neira, J.L., De Paepe, M., Cioffi, W.G., Ayala, A. 2007. Fas induced pulmonary apoptosis and inflammation during indirect acute lung injury. Amer. J. Resp. & Crit. Care. Med. (Epub ahead of print; PMID: 17600273).
Venet, F., Chung, C.S., Monneret, G., Huang, X., Horner, B., Garber, M.E., Ayala, A. 2008. T-regulatory cell populations in trauma and sepsis. J. Leuko. Biol. (provisionally accepted).
For more information on our laboratory’s Research, Grants/Awards, Teaching & Publications go to
Dr. Alfred Ayala's Brown Faculty page.
